What is Cholesterol – NEW Research

Does unresolved inflammation, or cholesterol cause heart disease and stroke? Why  does this WHO graph show heart (Ishaemic) disease and stroke as the leading cause of death, accounting for 15.2 million deaths in 2016, and the leading cause of death in the last 15 years? – If Heart Health’s advice is correct?

Heart  Disease and Stroke Top Global Cause Death 2016

Heart disease and stroke leading cause of death 2016
Top 10 Global Cause of Death – 2016 WHO

The following quote by a favored Human Anatomy and Physiology text says this about, what is cholesterol? – “Cholesterol is the raw ingredient for your sex hormones, testosterone, progesterone and estrogen.  Without cholesterol your adrenal glands would fail.  The pleasure of sex, relationships, and children would not exist. “Cholesterol is vital for homeostatis and it is essential for life” Says Chapter 2, Chemistry Comes Alive, Page 46-47, Tenth Edition, Human Anatomy & Physiology by Marieb and Hoehn.

Does Cholesterol Make Your Sex Hormones?

Lets look at two scientifically based diagrams, that  helped me understand – ‘What is Cholesterol?’

The first diagram shows that cholesterol is the structural basis for the manufacture of your steroid sex hormones. This has been used to illustrate a difference, between  pharmaceutically made steroid drugs (medications), and steroid fats naturally found in your body.

“The Biosynthetic Relationship of Classes of Steroid Hormones and Cholesterol” 

This means simple processes are turned into more complex processes.

 

What is Cholesterol

Cholesterol is shown as the precursor of your steroid sex hormones where it links down to Pregnenolone, and then the Progesterone (the female sex hormone progesterone is made here). The Androgens make the male sex hormone Testosterone and the female Estrogens. Mineralocorticoids named in the center, regulate your body’s excretion of electrolytes in urine from your bladder via the kidneys. Glucocorticoids, the name on the far left regulates stress.

How Sex Hormones Are Made in Your Body

The www.researchgate.net/ diagram does not include the Fat Type  of ‘Steroid’ in the explanation or title  of  “How Hormones Are Made in Your Body’ heading. This is why I have shown you the earlier diagram which is called “The Biosynthetic Relationship of Classes of Steroid Hormones and Cholesterol.”  

What is cholesterol

A Diagram of Your Sex Hormones Showing Cholesterol as Their Precursor 

START with Cholesterol at the top, then link down to PROGESTERON – go to blue TESTOSTERONE, then ESTRADIOL (E2) and ESTRONE (E1) which are known as the Estrogens.

Steroids – A Type of Fat Naturally Found in Your Body

“Structurally, steroids differ quite a bit from fats and oils. Steroids are basically fat molecules made of four interlocking hydrocarbon rings.  Like triglycerides, steroids are fat soluble and contain little oxygen. The single most important molecule in your steroid chemistry is cholesterol

Says Chapter 2, Chemistry Comes Alive, Page 47,

Tenth Edition, Human Anatomy & Physiology, Marieb and Hoehn.

 

“All steroids have the same basic skeletons and the chemical differences between them are slight.” But despite there being little chemical difference these steroid hormones are powerful and regulate a wide range of your body’s functions”

Says Chapter 18, Endocrine disease, Page 1048, 5th Edition,

Clinical Medicine. Kumar & Clark, W.B. Saunders.

 

How Steroid Fats Present  in Your Body 

What is Cholesterol

Cholesterol’s Family of Steroid Fats

What do HDL & LDL Lipoproteins Look Like?

Lipoproteins are made in your livers from triglycerides, protein, phospholipids, fat soluble vitamins, free cholesterol and cholesterol bound in fatty acids. This detailed image is from Mosby’s Medical Dictionary, 9th Edition.

HDL (high density lipoproteins) and LDL (low density lipoproteins) look like the image below.

Compare the diagrams for steroid fats, and the one of a lipoprotein.

 

 

What is Cholesterol

NOW – Compare the diagrams for: How Steroid Fats Present in Your Body, and What so HDL & LDL lipoproteins Look Like.

  1. Do you wonder if there has been a mix-up, in defining  Steroid Fats and Lipoproteins?
  2. Ask yourself – Why don’t the cholesterol steroid fats: cortisol, aldosterone, testosterone, progesterone  and estrogen not look like a lipoprotein?

 Low HDL and LDL Causes Early Death in Vulnerable Elderly Says Research

#1. RESEARCH SAYSYour Grandparents live longer if their total cholesterol levels are higher than 189mg/dl (4.9 mmol/L) even when many other related factors were considered. THIS MEANS – Your grandparents die sooner, if their total cholesterol levels are lower than 189mg/dl (4.9mmol/L) even when many other related factors have been taken into account, this 2003 study  found.

#2. RESEARCH SAYS – If your grandparents, or a parent, is chronically ill with heart failure, this 2000 research indicates, that they are less likely to survive if they have low blood concentrations of cholesterol.

#3. RESEARCH SAYS – Low total cholesterol, is a signal for higher deaths in elderly adults, who live in their own homes. This 12 year follow- up study of older adults reviewed research where the authors used different methods of analyzing the information. One researcher analyzed a group of home-dwelling elderly for 6 years and found more deaths occurred when their total cholesterol level was low. Overall results of this study reinforced the role that low total cholesterol levels were, as an indicator of higher death (mortality) rates when  other health problems were excluded.

Low Cholesterol Levels Increases Risk of Parkinson’s 

And paradoxically, high total cholesterol levels decrease your brains risk of developing Parkinson Disease. Cholesterol is a vital structural component of the cell membranes of your brain, and the entire nervous system located in your brain. The Rotterdam Study involved  6465 people aged over 55 years. At the start of this study they were all examined – then were re-examined 9.4 years later. It was discovered that higher total cholesterol levels, were associated with a lower number of the women members of the group developing Parkinson’s disease:

High Total Cholesterol LESSENS YOUR Risk of Getting Parkinson Disease.

Rotterdam Research Findings:

TOTAL CHOLESTEROL between: 6.8 – 7.0 mmol/L  –  (122 – 126 mg/dl)

INCREASED RISK of getting PARKINSON’S by  – 16%

TOTAL CHOLESTEROL between: 6.1 – 6.8 mmol/L  –  (110 – 122 mg/dl)

INCREASED RISK of getting PARKINSON’S  by  – 46%

TOTAL CHOLESTEROL Below: 6.1 mmol/L  –  (110 mg/dl)

INCREASED RISK of getting PARKINSON’S by  –  58%

 

 Are HDL and LDL Part of Your Innate Immune System?

It has been wrongly thought the sole purpose of HDL (high density lipoproteins), LDL (low density lipoproteins) and VLDL (very low density lipoproteins) in your blood was to transport fats.

CUMULATIVE RESEARCH:

“Suggests that lipoproteins may also prevent you getting infections from bacterial, viral or parasites and are therefore a component of innate immunity”.

Here is the  evidence of this research published in 2010:

Han R. Plasma lipoproteins are important components of the immune system.

Microbiol Immunol.2010 Apr;54(4):246-53. doi: 10.1111/j.1348-0421.2010.00203.x.

Lipoproteins seem to have been wrongly called cholesterol by the businesses of healthcare

Unbelievably plasma (blood) lipoproteins are important parts of your immune system – your innate immune system.

Your innate immunity is your body’s natural immune system. It is the FIRST LINE  or FRONT LINE of defense soldiers put into action by your immune system.

 

RESEARCH FOUND THAT:

 “Lipoproteins can detoxify lipopolysaccharides and lipoteichoic acid.”

Lipopolysaccharides (LPS) are signal like attachments, attached to bacteria, virus and parasites. LPS warn your first line of defense immune systems soldiers, that your body has harmful invaders.

Lipoteichoic acid is similar to LPS and triggers the release of some of your immune systems white blood cells so it can carry out a ‘passive kill attack’ on the invaders.

THE RESEARCHERS WHO DISCOVERED THIS IGNORED INFORMATION :

Caradonna L, Amati L, Magrone T, Pellegrino NM, Jirillo E, Caccavo D. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res. 2000;6(3):205-14.

Medical researchers have detected lipopolysaccharides and lipoteichoic acid in the blood of patients who have abnormal gut bacteria (microflora) or increase permeability of the intestinal mucosa.

This is commonly known as leaky gut syndrome. Research has found lipoproteins bind to lipopolysaccharides (LDS) thereby preventing attacks and neutralizing harmful invaders.

THE RESEARCHERS WHO DISCOVERED THIS VITAL INFORMATION :

Rauchhaus M,Coats AJ,Anker SD. The endotoxin-lipoprotein hypothesis. Lancet.2000 Sep 9;356(9233):930-3.

Does this research mean cholesterol, or more correctly lipoproteins, are part of your first line of defense, immune systems soldiers and not the cause of heart disease?

ASK YOURSELF THIS

Why is Heart Disease and Stroke the Leading Cause of Death for the Last 15 years?
Why is Heart Disease and Stroke the #1 KILLER in 2016?

Look at the WHO (World Health Organizations graph showing the Top 10 causes of death globally. Ischaemic (Ischemic) heart disease and Stroke at the top 2 lines. Ishaemic means death from lack of oxygen to your heart.

Top 10 Global Cause Death in 2016

http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

Heart disease and stroke leading cause of death 2016
If  you think cholesterol is made from the fat in your diet, go here and learn the proper science.

#1. You are so welcome here

#2. Has this science based information shocked you, or clarified some niggles you’ve had in your mind? 

#3. Is Heart Health Medicines treatment and advice correct?

 

 

 

 

 

6 Replies to “What is Cholesterol – NEW Research”

  1. This is all very interesting. I have always been told to keep the cholesterol down, how come doctors etc tell you this but then the science shows something else?
    What food would you recommend eating? Is there a limit from when your body starts needing more?

    1. Hi Alexander, Thank you for viewing my first post. Here is a question in my next post that may help. Why is Heart Disease & Stroke the #1 KILLER according to the WHO if the Heart Health Industries Treatment is correct? Here is the link the the 2016 WHO graph https://cholesteroldetectives.com/8-high-cholesterol-myths-vs-facts-new-research/
      Food and diet revolves around the recommendations of 3 Cardiologists who have changed their recommendations.- This is shared in post 4. The next post “Does Your Body Make Cholesterol? Science Says YES explains and shows your how cholesterol is made.
      Thanks again for taking on this challenge for me Alexander, I really appreciate your feedback.

  2. Hi, I found it very interesting the fact that I high level of cholesterol lower the risk of Parkinson.

    The human body is such an intricate machine where one thing depends on the other. And he will never stop learning new things about it.

    Is there a perfect level of cholesteroal so that don’t suffer any disease?

    Thanks for this valuable information!

    1. Hi Stefan, Thanks for your time. Unresolved inflammation NOT cholesterol is one of the hidden drivers of heart disease, according to 3 Cardiologists I’ll be featuring soon. Cholesterol is a vital essential nutrient ingredient. The tests, the medical appointments, and the cholesterol lowering drugs support a $billion industry…which is unbelievable. Diets and food that drive inflammation are at the root cause. Foods like omega 6 plant oils drive inflammation – an omega 3 blood test is one I’ll be offering soon.
      Go well Stefan

  3. Hi. It is interesting to learn that we need cholesterol in our bodies and that we actually manufacture it ourselves. So all of the advice by doctors who prescribe statins for lowering ‘high cholesterol’ is wrong? If we need it to make our sex hormones, then we need it! Lowering our cholesterol level does not seem to benefit us in any at all, but is actually detrimental to our overall health.
    Thanks for sharing this information.

    1. Hey Andrew, Yes cholesterol is vital for our quality of health and wellbeing as well as being a sex hormone manufacturing ingredient. Statins are a billion dollar industry. More about that in another post. Thankfully some Cardiologists have found that it is inflammation not cholesterol blocking arteries. Thank you for your contribution.

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