What is Cholesterol – NEW Research

By | January 28, 2019

Does unresolved inflammation, or cholesterol, cause heart disease and stroke? Why  does this WHO graph show heart (Ishaemic) disease and stroke as the leading cause of death, accounting for 15.2 million deaths in 2016, and the leading cause of death in the last 15 years? 

Is Heart Health’s Advice Correct?

Heart  Disease and Stroke Top Global Cause Death 2016

Heart disease and stroke leading cause of death 2016

Top 10 Global Cause of Death – 2016 WHO

“Cholesterol is the raw ingredient for your sex hormones, testosterone, progesterone and estrogen.  Without cholesterol your adrenal glands would fail.  The pleasure of sex, relationships, and children would not exist. “Cholesterol is vital for homeostatis and it is essential for life” Says Chapter 2, Chemistry Comes Alive, Page 46-47, Tenth Edition, Human Anatomy & Physiology by Marieb and Hoehn.

What is Cholesterol-NEW Research Shows Cholesterol Makes Your Sex Hormones?

Lets look at two scientifically based diagrams, that  helped me understand – ‘What is Cholesterol?’

The first diagram shows that cholesterol is the structural basis for the manufacture of your steroid sex hormones. This has been used to illustrate a difference, between  pharmaceutically made steroid drugs (medications), and steroid fats naturally made in your body.

“The Biosynthetic Relationship of Classes of Steroid Hormones and Cholesterol” 

This means simple processes are turned into more complex processes.

What is Cholesterol

Cholesterol is shown as the precursor of your steroid sex hormones where it links down to Pregnenolone, and then the Progesterone (the female sex hormone progesterone is made here). The Androgens make the male sex hormone Testosterone and the female Estrogens. Mineralocorticoids named in the center, regulate your body’s excretion of electrolytes in urine from your bladder via the kidneys. Glucocorticoids, the name on the far left regulates stress.

How Sex Hormones Are Made in Your Body

The www.researchgate.net/ diagram does not include the Fat Type Name  of ‘Steroid’ in the explanation or title  of  “How Hormones Are Made in Your Body’ heading. This is why I have shown you the earlier diagram which is called “The Biosynthetic Relationship of Classes of Steroid Hormones and Cholesterol.”  

What is cholesterol

A Diagram of Your Sex Hormones Showing Cholesterol as Their Parent ingredient 

START with Cholesterol at the top, then link down to PROGESTERON then go to blue TESTOSTERONE, then ESTRADIOL (E2) and ESTRONE (E1). These are known as the Estrogens.

Steroids – A Type of Fat Naturally Found in Your Body

“Structurally, steroids differ quite a bit from fats and oils. Steroids are basically fat molecules made of four interlocking hydrocarbon rings.  Like triglycerides, steroids are fat soluble and contain little oxygen. The single most important molecule in your steroid chemistry is cholesterol

Says Chapter 2, Chemistry Comes Alive, Page 47, Tenth Edition, Human Anatomy & Physiology, Marieb and Hoehn.

“All steroids have the same basic skeletons and the chemical differences between them are slight.” But despite there being little chemical difference these steroid hormones are powerful and regulate a wide range of your body’s functions”

Says Chapter 18, Endocrine disease, Page 1048, 5th Edition, Clinical Medicine. Kumar & Clark, W.B. Saunders.

How Steroid Fats Present  in Your Body 

What is Cholesterol

Cholesterol’s Family of Steroid Fats

What do HDL & LDL Lipoproteins Look Like?

Lipoproteins are made in your livers from triglycerides, protein, phospholipids, fat soluble vitamins, free cholesterol and cholesterol bound in fatty acids. This detailed image is from Mosby’s Medical Dictionary, 9th Edition.

HDL (high density lipoproteins) and LDL (low density lipoproteins) look like the image below.

Compare the diagrams for steroid fats, and the one of a lipoprotein.

What is Cholesterol

NOW – Compare the diagrams for: How Steroid Fats Present in Your Body.

What do HDL & LDL lipoproteins Look Like?

  1. Do you wonder if there has been a mix-up, in defining  Steroid Fats and Lipoproteins?
  2. Ask yourself – Why don’t the cholesterol steroid fats: cortisol, aldosterone, testosterone, progesterone  and estrogen not look like a lipoprotein?

 Low HDL and LDL Causes Early Death in Vulnerable Elderly Says Research

#1. RESEARCH SAYSYour Grandparents live longer if their total cholesterol levels are higher than 189mg/dl (4.9 mmol/L) even when many other related factors were considered. THIS MEANS – Your grandparents die sooner, if their total cholesterol levels are lower than 189mg/dl (4.9mmol/L) even when many other related factors have been taken into account, this 2003 study  found.

#2. RESEARCH SAYS – If your grandparents, or a parent, is chronically ill with heart failure, this 2000 research indicates, that they are less likely to survive if they have low blood concentrations of cholesterol.

#3. RESEARCH SAYS – Low total cholesterol, is a signal for higher deaths in elderly adults, who live in their own homes. This 12 year follow- up study of older adults reviewed research where the authors used different methods of analyzing the information. One researcher analyzed a group of home-dwelling elderly for 6 years and found more deaths occurred when their total cholesterol level was low. Overall results of this study reinforced the role that low total cholesterol levels were, as an indicator of higher death (mortality) rates when  other health problems were excluded.

Low Cholesterol Levels Increases Risk of Parkinson’s 

And paradoxically, high total cholesterol levels decrease your brains risk of developing Parkinson Disease. Cholesterol is a vital structural component of the cell membranes of your brain, and the entire nervous system located in your brain. The Rotterdam Study involved  6465 people aged over 55 years. At the start of this study they were all examined – then were re-examined 9.4 years later. It was discovered that higher total cholesterol levels, were associated with a lower number of the women members of the group developing Parkinson’s disease:

High Total Cholesterol Lessens Your Risk of Getting Parkinson Disease.

The Rotterdam Study involved 6465 people aged over 55 years. It was published in The Oxford Academic American Journal of Epidemiology 2006. At the start of this study they were all examined – then were re-examined 9.4 years later. It was discovered that higher total cholesterol levels, were associated with a lower number of the women members of the group developing Parkinson’s disease.

Here are the surprising findings of the Rotterdam study:


  • BELOW 6.1 mmol/L (110 mg/dl) increased Parkinson risk by 58%
  • BETWEEN 6.1 – 6.8 mmol/L (110 – 122 mg/dl) increased Parkinson risk by 46%
  • BETWEEN 6.8 – 7.0 mmol/L (122 – 126 mg/dl) increased Parkinson risk by 16%

  Are HDL and LDL Part of Your Innate Immune System?

It has been wrongly thought the sole purpose of HDL (high density lipoproteins), LDL (low density lipoproteins) and VLDL (very low density lipoproteins) in your blood was to transport fats.

CUMULATIVE RESEARCH“Suggests that lipoproteins may also prevent you getting infections from bacterial, viral or parasites and are therefore a component of innate immunity”.

Here is the  evidence of this research published in 2010:

  • Han R. Plasma lipoproteins are important components of the immune system. Microbiol Immunol.2010 Apr;54(4):246-53. doi: 10.1111/j.1348-0421.2010.00203.x.

Lipoproteins seem to have been wrongly called cholesterol by the businesses of healthcare

  • Unbelievably plasma (blood) lipoproteins are important parts of your immune system – your innate immune system.
  • Your innate immunity is your body’s natural immune system. It is the FIRST LINE  or FRONT LINE of defense soldiers put into action by your immune system.



  • Caradonna L, Amati L, Magrone T, Pellegrino NM, Jirillo E, Caccavo D. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res. 2000;6(3):205-14.
  • Medical researchers have detected lipopolysaccharides and lipoteichoic acid in the blood of patients who have abnormal gut bacteria (microflora) or increase permeability of the intestinal mucosa. This is commonly known as leaky gut syndrome. Research has found lipoproteins bind to lipopolysaccharides (LDS) thereby preventing attacks and neutralizing harmful invaders.


Does this research mean cholesterol, or more correctly lipoproteins, are part of your first line of defense, immune systems soldiers and not the cause of heart disease?

CONCLUSION: What is Cholesterol-NEW Research

Cholesterol is a vital structural component of the cell membranes of your brain, and the entire nervous system located in your brain.

Read about 9 Ways Cholesterol is Needed by Your Body

And here, their are 12 evidenced based issues that are linked to the cause of heart disease.


What do you think about cholesterol’s role in your body?

Please leave your comments below.


Citizen Science by RJ an Evidence-Based Investigator


6 thoughts on “What is Cholesterol – NEW Research

  1. Alexandra

    This is all very interesting. I have always been told to keep the cholesterol down, how come doctors etc tell you this but then the science shows something else?
    What food would you recommend eating? Is there a limit from when your body starts needing more?

    1. admin

      Hi Alexander, Thank you for viewing my first post. Here is a question in my next post that may help. Why is Heart Disease & Stroke the #1 KILLER according to the WHO if the Heart Health Industries Treatment is correct? Here is the link the the 2016 WHO graph https://cholesteroldetectives.com/8-high-cholesterol-myths-vs-facts-new-research/
      Food and diet revolves around the recommendations of 3 Cardiologists who have changed their recommendations.- This is shared in post 4. The next post “Does Your Body Make Cholesterol? Science Says YES explains and shows your how cholesterol is made.
      Thanks again for taking on this challenge for me Alexander, I really appreciate your feedback.

  2. Stefan

    Hi, I found it very interesting the fact that I high level of cholesterol lower the risk of Parkinson.

    The human body is such an intricate machine where one thing depends on the other. And he will never stop learning new things about it.

    Is there a perfect level of cholesteroal so that don’t suffer any disease?

    Thanks for this valuable information!

    1. admin

      Hi Stefan, Thanks for your time. Unresolved inflammation NOT cholesterol is one of the hidden drivers of heart disease, according to 3 Cardiologists I’ll be featuring soon. Cholesterol is a vital essential nutrient ingredient. The tests, the medical appointments, and the cholesterol lowering drugs support a $billion industry…which is unbelievable. Diets and food that drive inflammation are at the root cause. Foods like omega 6 plant oils drive inflammation – an omega 3 blood test is one I’ll be offering soon.
      Go well Stefan

  3. Andrew

    Hi. It is interesting to learn that we need cholesterol in our bodies and that we actually manufacture it ourselves. So all of the advice by doctors who prescribe statins for lowering ‘high cholesterol’ is wrong? If we need it to make our sex hormones, then we need it! Lowering our cholesterol level does not seem to benefit us in any at all, but is actually detrimental to our overall health.
    Thanks for sharing this information.

    1. admin

      Hey Andrew, Yes cholesterol is vital for our quality of health and wellbeing as well as being a sex hormone manufacturing ingredient. Statins are a billion dollar industry. More about that in another post. Thankfully some Cardiologists have found that it is inflammation not cholesterol blocking arteries. Thank you for your contribution.


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